Neuroprotective Role of a Novel Copper Chelator against A𝜷₄₂ Induced Neurotoxicity

Figure 7

Scanning electron micrographs showing eye degeneration and their rescue after compound (L) treatment ((e)–(l)). Upper panel shows the digital images of compound eyes of wild type (a), Aβ expressing (b), Aβ in presence of copper (c), and Aβ with Cu + chelator (d). There is a reduction in size of eye of Aβ expressing fly grown in normal food ((b), (f)) as compared to the wild type ((a), (e)) and more degeneration can be seen after treatment with Cu (500 μM) alone ((c), (g)). Rescue after the treatment with 250 μM of compound (L) ((d), (h)). Magnification is 230x. Lower panel shows the eye phenotypes of corresponding images of middle panels, respectively, ((e)–(h)) showing very distinct pattern of eye degeneration and ommatidia disruption. Magnification is 700x.

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