Preferential Selectivity of Inhibitors with Human Tau Protein Kinase Gsk3𝜷 Elucidates Their Potential Roles for Off-Target Alzheimer’s Therapy

Table 3

Structures of 7 potential small molecule inhibitors and their relative binding affinities (IC₅₀ and 𝐾_𝑖) values.

Sl. number	Ligand	Molecular formula	Molecular weight (Da)	IC50-median inhibition concentration value	𝐾𝑖-inhibition constant value
(1)		[C16 H11 Cl N4 O3 S]; [Drug Bank ID DB07794]	374.80	2000 nM	600 nM
(2)		[C18 H13 N7]	327.34	1900 nM	140 nM
(3)		[C27 H28 N4 O2 S]	472.60	3200 nM	3200 nM
(4)		[C19 H20 F N5]	337.39	130 nM	n/a
(5)		[C13 H12 N2 O]; [Drug Bank ID DB07919]	212.25	350 nM	n/a
(6)		[C11 H15 N5]	217.27	3200 nM	n/a
(7)		[C25 H22 N6 O2]	438.48	2.1 nM	n/a