Studies on Interaction of Buffalo Brain Cystatin with Donepezil: An Alzheimer's Drug

Table 1

Inhibitory activity of cystatin in the presence of donepezil.

S. no	Drug concentration	% Remaining inhibitory activity of cystatin
1	Cystatin alone	100
2	Cystatin + 0.16 μM donepezil	57±0.623
3	Cystatin + 0.32 μM donepezil	40±0.938
4	Cystatin + 0.64 μM donepezil	38±0.772
5	Cystatin + 0.96 μM donepezil	24±0.932
6	Cystatin + 1.6 μM donepezil	15±0.680

All data are expressed as mean ± S.E. for three different sets of experiments; statistical significance was conducted employing one way ANOVA. A probability level of 0.05 was selected showing that results are significant.