Research Article
Identification and Preclinical Pharmacology of the -Secretase Modulator BMS-869780
Table 2
PK/PD model values from mouse and rat studies.
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Kel-first order rate constant for drug elimination; -volume of distribution; Ka rate constant for drug absorption; -first order rate constant for degradation of A1-42 or A1-40; -plasma concentration required for 50% inhibition of Aβ1-42 or Aβ1-40 production; is the response in Aβ1-42 or Aβ1-40 levels, assumed 100% at time zero, ; -range of the response of Aβ1-42 or Aβ1-40 levels; -zero order constant for Aβ1-42 or Aβ1-40 production. |