Research Article
Neprilysin Is Poorly Expressed in the Prefrontal Cortex of Aged Dogs with Cognitive Dysfunction Syndrome
Table 1
Characteristics and NEP expression values of the animals.
| Dogs | Breed | Sex | Cause of death | Age (years) | NEP expression (ru) |
| Young (2–4 years) | 1 | Mongrel | F | Babesiosis | 4.0 | 0.706 | 2 | Beagle | M | Hunting injuries | 4.0 | 4.705 | 3 | Epagneul Breton | M | Hunting injuries | 2.0 | 0.669 | 4 | Ibizan Hound | M | Urethral rupture | 3.0 | 1.308 | 5 | Mongrel | M | Car accident | 4.0 | 3.902 | 6 | Mongrel | M | Rodenticide toxicosis | 3.0 | 1.627 | | | | Mean ± S.D. | 3.3 ± 0.8 | 2.15 ± 1.72 |
| Aged-CU (11–16 years) | 7 | Mongrel | M | Urolithiasis | 16.0 | 0.961 | 8 | Mongrel | F | Mammary tumors | 14.0 | 2.298 | 9 | Teckel | F | Intervertebral disk disease | 13.0 | 3.888 | 10 | Fox Terrier | M | Chronic kidney disease | 12.0 | 3.864 | 11 | Mongrel | M | Tracheal collapse, bronchitis | 11.0 | 1.014 | 12 | Toy poodle | M | Mitral valve disease | 16.0 | 1.462 | | | | Mean ± S.D. | 13.7 ± 2.1 | 2.25 ± 1.35 |
| Aged-CI (12–17 years) | 13 | Chiwawa | M | Severe cognitive damage | 17.5 | 0.571 | 14 | Mongrel | M | Severe cognitive damage | 16.0 | 0.366 | 15 | Cocker Spaniel | M | Severe cognitive damage | 12.8 | 0.199 | 16 | Toy poodle | F | Severe cognitive damage | 14.0 | 0.671 | 17 | Pekingese | M | Severe cognitive damage | 16.0 | 0.696 | 18 | West Highland | F | Severe cognitive damage | 14.0 | 0.173 | | | | Mean ± S.D. | 15.05 ± 1.7 | 0.45 ± 0.23 |
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