Altered Proteolysis in Fibroblasts of Alzheimer Patients with Predictive Implications for Subjects at Risk of Disease

Figure 2

TK-ab determination in cultured dermal fibroblasts. Total protein extracts from 29 healthy control subjects, 12 neurological non-AD patients (neurol controls), 36 probable AD patients, 5 early-onset (dominant AD) patients, and 38 first-degree relatives of AD patients (AD relatives) were analysed for TK-ab expression as described in Figure 1. TK-ab-negative and -positive cases are represented by open and closed circles, respectively.