Research Article

Differential Network Analyses of Alzheimer’s Disease Identify Early Events in Alzheimer’s Disease Pathology

Table 3

Significant biological processes of the low TO genes that have a larger number of links in the coexpression network of a particular region.

Number of low
TO genes
Number of genes with high
connectivity in region
Significant biological processes/pathways

204 EC-HIP 115 genes in EC Regulation of response to stress
Cell adhesion-ephrin signaling
Apoptosis and survival-NO synthesis and signaling
Cell cycle-chromosome condensation in prometaphase
95 genes in HIP Mitochondrial translational termination
Regulation of protein exit from endoplasmic reticulum
DNA damage-ATM/ATR regulation of G1/S checkpoint
Immune response

140 EC-MTG 84 genes in EC Cell adhesion
Signal transduction cAMP signaling
Positive regulation of transcription elongation from RNA polII promoter
Regulation of transcription involved in G1 phase (mitotic cell cycle)
Regulation of G2/M transition of mitotic cell cycle
Apoptosis and survival
56 genes in MTG Negative regulation of stress activated MAPK cascade
Negative regulation of signal transduction
Activation of astroglial cells proliferation by ACM3
Notch signaling pathway
Regulation of lipid metabolism

242 EC-PCC 130 genes in EC Generation of signal involved in cell-cell signaling
Positive regulation of mitotic cell cycle
118 genes in PCC Proteolysis role of parkin
Immune response IL6 signaling pathway
p53 signaling pathway
Activation of ESR1/SP pathway

125 HIP-MTG 59 genes in HIP Oxidative phosphorylation
Neuroligin clustering
Gephyrin clustering
Postsynaptic membrane assembly
Cholesterol and sphingolipids transport
66 genes in MTG Transcription
GTP-XTP metabolism
ATP/ITP metabolism
Osmosensory signaling pathway
Ribonucleotide metabolic process

312 HIP-PCC 145 genes in PCC Cell adhesion-ephrin signaling
Immune response
Negative adaptation of signaling pathway
174 genes in HIP Memory and learning
Regulation of dopamine metabolic process
Cognition
Regulation of calcium ion transport
NMDA-dependent postsynaptic long-term potentiation
DNA damage, apoptosis, and survival

158 PCC-MTG 83 genes in PCC Positive regulation of protein tyrosine kinase activity
Neural plate elongation
Ubiquinone metabolism
PEDF signaling
Cytoskeleton remodeling-RalB regulation pathway
Antiapoptotic TNFs/NF-kB/IAP pathway
77 genes in MTG Glucocorticoid receptor signaling
Positive regulation of transport