PET Imaging of Epigenetic Influences on Alzheimer’s Disease

Table 1

PET radiotracers for visualizing epigenetic influences on Alzheimer’s disease.

PET radiotracer	Measurement	Related epigenetic mechanism	Reference
^18FFAHA	Class 2a HDAC	Histone modification, HDAC activity	Yeh et al., 2013 [31]
^18FSAHA	Class 1 and 2b HDAC	Histone modification, HDAC activity	Hendricks et al., 2011 [32]
^64CuCUDC-101	HDAC	Histone modification, HDAC activity	Meng et al., 2013 [33]
^18FFDG	Glucose	DNA methylation, metabolic activity	Mosconi et al., 2008 [52]; Dukart et al., 2013 [61]
^11CPiB	Amyloid-beta	Molecular production of Aβ	Rabinovici et al., 2011 [23]; Hatashita and Yamasaki, 2013 [62]
^18Fflorbetapir	Amyloid-beta	Molecular production of Aβ	Clark et al., 2011 [54]; Huang et al., 2013 [56]
^18Fflorbetaben	Amyloid-beta	Molecular production of Aβ	Ong et al., 2013 [59]
^18Fflutemetamol	Amyloid-beta	Molecular production of Aβ	Thurfjell et al., 2012 [60]
^18FAV-1451	Tau protein	Phosphorylation of tau protein	Marquie et al., 2015 [63]
^18FTHK	Tau protein	Phosphorylation of tau protein	Shah and Catafau, 2014 [64]