Comparative Neuroprotective Effects of Dietary Curcumin and Solid Lipid Curcumin Particles in Cultured Mouse Neuroblastoma Cells after Exposure to Aβ42

Figure 6

Aβ42-induced p-tau was decreased by SLCP treatment. (a-b) N2a cells were treated with Aβ42 (10 μM) for 24 h in absence or presence of different concentrations of SLCP. The p-tau immunofluorescent signal was significantly increased after Aβ42 exposure ( relative to control) and normalized by SLCP (1 μM) treatment. Scale bar indicates 50 μm and is applicable to all other images. (c–e) Western blot data showed that p-tau (S422) was significantly increased by Aβ42 exposure, whereas SLCP treatment protected against such increase at 10, 1, and 0.1 μM levels (, in comparison to all other groups with different concentrations of SLCP treatment, except those given 0.01 μM).

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