Decreased C3 Activation by the devR Gene-Disrupted Mycobacterium tuberculosis Strain in Comparison to the Wild-Type Strain

Figure 1

Pattern of C3 activation by the different mycobacterial strains. (a) C3 activation through classical pathway by devR mutant, complemented, and wild-type M. tuberculosis H37Rv mycobacterial strains. (b) C3 activation through alternative pathway by devR mutant, complemented, and wild-type M. tuberculosis H37Rv mycobacterial strains. ^∗𝑃<0.05; ^∗∗𝑃<0.01. The shaded bars represent limits of C3 activation by blocking complement activation using normal human serum diluted in PBST-EDTA.

(a)  C3 activation through classical pathway

(b) C3 activation through alternative pathway