CXCR4 and Axillary Lymph Nodes: Review of a Potential Biomarker for Breast Cancer Metastasis

Table 1

CXCR4 and lymph node metastasis in recent studies.

Study	Findings	value
Hao et al. [35]	↑CXCR4 with ↑TNM stage	<0.037
	↑CXCR4 with +lymph node mets	<0.001
	↑CXCR4/VEGF w/+LN mets	0.007
	↑CXCR4/MMP-9 w/+LN mets	<0.001
Kang et al. [36]	↑CXCR4 in +LN tumors over −LN tumors	0.03
	↑CXCR w/OS or distant mets-not observed in this data	—
Parker et al. [37]	↑CXCR4 w/+LN had worse 5 yr OS	0.02
Cabioglu et al. [38]	↑CXCR4 w/+LN	0.113
Su et al. [39]	↑CXCR4 (cytoplasmic) with +LN mets	0.0325

CXCR4: CXC chemokine receptor 4, LN mets: lymph node metastases, MMP-9: matrix metalloproteinase-9, VEGF: vascular endothelial growth factor.