Effect of Berry Extracts and Bioactive Compounds on Fulvestrant (ICI 182,780) Sensitive and Resistant Cell Lines
Figure 3
Effect of berry extracts proliferation on ICI-resistant (ZR75-1R) cell line without and with ICI. Cell proliferation results from 6 d treatment of RRE on ZR75-1R. Vehicle treatment contained 0.01% EtOH and 0.1% DMSO. All treatments (including ICI) were normalized to the appropriate vehicle treatment. Data represented is mean standard error of three individual experiments performed in triplicate for each treatment. The means were tested for difference using a -test and a considered significant. The significantly different means compared to vehicle control (#) or ICI-only treatment (*) are indicated. The relative index (RI) was calculated using the formula RI = (expected)/(observed) = , where and , are extract and ICI, respectively [28]. An RI = 1 was considered additive, <1 antagonism or absence of synergism, and >1 presence of synergism.
