Prognostic Significance of Tissue Inhibitor of Metalloproteinase-1 in Breast Cancer

Table 1

Clinicopathologic features of the patients included in the gene expression microarray analysis.

		Univariate analysis
		Recurrence			Death
		HR	95% CI	𝑃	HR	95% CI	𝑃
Number of patients	176
Age at diagnosis
Median	52 years
Range	26–89 years
Recurrence
Events	91 (52%)
Death
Events	68 (39%)
ER status
Negative	64 (36%)	1.54	1.00–2.38	0.05	2.23	1.37–3.65	0.001
Positive	112 (64%)
HER2 status
Non-amplified	146 (83%)	1.07	0.62–1.83	0.82	0.87	0.46–1.67	0.67
Amplified	30 (17%)
Grade
3	120 (68%)	1.67	1.04–2.69	0.03	2.00	1.13–3.56	0.02
1-2	56 (32%)
Stage
I	44 (25%)	1.03	0.61–1.73	0.91	1.71	0.85–3.46	0.13
IIA/IIB	118 (67%)
IIIA/IIIB	14 (8%)
Gene expression microarray score; for TIMP-1
Range	−5.80–4.38	1.64	1.02–2.61	0.04	1.29	0.74–2.23	0.37
≥0.84	38 (21.6%)
<0.84	138 (78.4%)

𝑃 values correspond to univariate Cox regression analysis. HR hazard ratio.