The Ongoing Revolution in Breast Imaging Calls for a Similar Revolution in Breast Pathology

Figure 4

Right (a) and left (b) mammograms, mediolateral oblique projections. Subtle architectural distortion and parenchymal contour change are confirmed on the microfocus mammographic image (c) of the left breast (encircled). Hand-held ultrasound (d) and automated, 3D ultrasound (e) images confirm the presence of malignancy and suggest multifocality. Magnetic resonance examination in the sagittal (f, g) and axial (h, i) planes demonstrates fifteen separate malignant tumor foci. Since only 3 invasive tumor foci were described on the postsurgical histopathology report, the remainder of the mastectomy specimen was also prepared for microscopic examination. Three subgross (3D) histology slices from the reexamination of the mastectomy specimen (j, l, n) and photomicrographic magnification of the areas containing the 12 additional individual invasive cancer foci (k, m, o). This reexamination completes the radiologic-pathologic correlation.