Review Article
Radiation Therapy for Locally Recurrent Breast Cancer
Table 2
Outcomes of patients treated with repeat breast conserving therapy following in-breast local recurrence.
| Study | Number of patients | Median followup (months) | RT technique | Repeat RT dose (Gy) | ≥ Grade 3 toxicity (%) | Local control (%) | Overall survival (%) |
| Deutsch [15] | 39 | 51.5 | EBRT | 50* | NR | 76.9 | 77.9‡ | Hannoun-Levi et al. [18] | 69 | 50.2 | Brachytherapy | 30 or 45–50 | 10.2 | 77.4 | 91.8‡ | Kraus-Tiefenbacher et al. [17] | 15 | 26 | IORT | 20* | 0 | 100 | 93.3¥ | Würschmidt et al. [16] | 4 | NR | NR | NR | 0 | NR | NR | Chadha et al. [22] | 15 | 36 | Brachytherapy | 30 or 45 | 0 | 89 | | Guix et al. [21] | 36 | 89 | Brachytherapy | 30 | 0 | 89.4** | 96.7** | Kauer-Dorner et al. [20] | 39 | 57 | Brachytherapy | 50.1† | 16.7 | 93 | 87‡ |
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NR: not reported, Gy: Gray, RT: radiation therapy, EBRT: external beam radiation therapy, IORT: intraoperative radiation therapy.
*Median, †mean, ‡at 5 years, **10-year actuarial, ¥at median followup.
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