Preclinical Evaluation of Oncolytic Δγ₁34.5 Herpes Simplex Virus Expressing Interleukin-12 for Therapy of Breast Cancer Brain Metastases

Table 1

Key features of the human breast cancer cell lines used in this study. Some lines can be classified into more than one subtype. Expression of ER and PR and amplification/overexpression of HER2 are indicated (+).

Cell line	Cancer type	Molecular subtype	Age of donor	Site of isolation	Receptor status			References
					ER	PR	HER2
BT-474	IDC	Luminal A/B	60	Primary tumor	−	+	+	[11–14]
MDA-MB-361	AC	Luminal A	40	Brain	+	+	+	[12, 13, 15–17]
MDA-MB-231	AC	Basal	51	Pleural effusion	−	−	−	[13–17]
SK-BR-3	AC	Luminal B/HER2	43	Pleural effusion	−	−	+	[12–14, 18]
ZR-75-1	DC	Luminal A	63	Ascites	+	+	+	[12–14, 19]

AC: adenocarcinoma, DC: ductal carcinoma, ER: estrogen receptor, HER2: human epidermal growth factor receptor 2, IDC: invasive ductal carcinoma, and PR: progesterone receptor.