PKC𝜶 and ER𝜷 Are Associated with Triple-Negative Breast Cancers in African American and Caucasian Patients

Table 1

Clinicopathological characteristics of 198 infiltrating ductal carcinomas.

	Caucasian	African American	Total	𝑃 value*
	N (%)	N (%)	N (%)
PKCα+	71 (76)	83 (79)	154 (78)	0.648
PKCα−	22 (24)	22 (21)	44 (22)
ERα+	63 (68)	55 (52)	118 (60)	0.028**
ERα−	30 (32)	50 (48)	80 (40)
ERβ+	65 (70)	72 (69)	137 (69)	0.847
ERβ−	28 (30)	33 (31)	61 (31)
ERβ+ (nuc + cyto)	11 (17)	21 (29)	32 (23)
ERβ+ (nuc)	41 (63)	37 (51)	78 (57)	0.221
ERβ+ (cyto)	13 (20)	14 (19)	27 (20)
ERα+/ERβ+	49 (53)	40 (38)	89 (45)	0.108
ERα+/ERβ−	14 (15)	15 (14)	29 (15)
ERα−/ERβ+	16 (17)	32 (30)	48 (24)
ERα−/ERβ−	14 (15)	18 (17)	32 (16)
Subtype^#
Luminal A	32 (35)	26 (26)	58 (30)
Luminal B	30 (33)	29 (28)	59 (31)	0.205
Her2+	13 (14)	18 (18)	31 (16)
TNBC	16 (18)	29 (28)	45 (23)
Grade^†
1	6 (13)	6 (8)	12 (10)
2	21 (46)	21 (29)	42 (35)	0.068
3	19 (41)	46 (63)	65 (55)
Lymph node+	28 (35)	52 (58)	80 (47)	0.0024**
Lymph node−	53 (65)	38 (42)	91 (53)
Tumor size	2.17 (1.47)	2.97 (1.87)	2.60 (1.73)	0.0007**
Mean (SD)
Age
<50	28 (30)	45 (43)	73 (37)	0.064
≥50	65 (70)	60 (57)	125 (63)

* All 𝑃 values were calculated using the Chi-square test. **𝑃<0.05; ^#Five patients categorized as ER−/PR+/Her2− were not assigned to a subtype category (3 African American, 2 Caucasian patients).
^†Tumor grade was available on 46/93 Caucasian patients and 73/105 African American patients.