PKC𝜶 and ER𝜷 Are Associated with Triple-Negative Breast Cancers in African American and Caucasian Patients

Table 5

(a) High tumor grade correlates with elevated PKCα expression. (b) PKCα and tumor grade is correlative in AA but not in Caucasian patients.

(a)

Outcome	Median (Minimum, maximum)			𝑃 value*
	Grade = 1 (𝑁=12)	Grade = 2 (𝑁=42)	Grade = 3 (𝑁=65)
PKCα (freq)	0.50 (0, 3)	2.00 (0, 4)	3.00 (0, 4)	0.010^††
PKCα (int)	0.50 (0, 3)	1.00 (0, 3)	2.00 (0, 4)	0.012^†
PKCα (sum)	1.00 (0, 6)	3.50 (0, 7)	5.00 (0, 8)	0.004^††

* 𝑃 value is based on the Kruskal-Wallis Test. ^†𝑃 value <0.05; ^††𝑃 value <0.01.

(b)

Race	Outcome	Median (Minimum, maximum)			𝑃 value*
		Grade=1 (𝑁=6)		Grade=3 (𝑁=46)
	PKCα (freq)	0 (0, 1)	2 (0, 3)	2 (0, 4)	0.007^††
AA (𝑁=73)	PKCα (int))	0 (0, 3)	1 (0, 3)	2 (0, 3)	0.017^†
	PKCα (sum)	0 (0, 4)	3 (0, 5)	5 (0, 7)	0.003^††
		Grade = 1 (𝑁=6)	Grade = 2 (𝑁=21)	Grade = 3 (𝑁=19)
	PKCα (freq)	2.5 (0, 3)	2 (0, 4)	3 (0, 4)	0.248
Caucasian (𝑁=46)	PKCα (int)	1.5 (0, 3)	2 (0, 3)	2 (0, 4)	0.277
	PKCα (sum)	4.0 (0, 6)	4 (0, 7)	5 (0, 8)	0.169

* 𝑃 value is based on the Kruskal-Wallis Test. ^†𝑃 value <0.05; ^††𝑃 value < 0.01.