Growth pathways in breast cancer. Key receptors are shown phosphorylated upon ligand binding, a chemical change that triggers downstream growth and proliferation pathways. Receptor crosstalks between receptors are shown by dotted arrows that can be chased by numbers: 1: Her2-FAK, 2: Her2-Met, 3: ER-Her2, 4: Ret-Her2. BCCM: breast cancer cell membrane; MMP: matrix metalloproeinases; A1B1: ER coactivator. For details of signaling pathways see the text.
