Metabolic Syndrome and Triple-Negative Breast Cancer: A New Paradigm

Figure 1

The insulin-leptin-adiponectin axis and risk of TNBC. Schematic representation demonstrates interactions of components in blood. After the compounds enter a normal breast cell, changes in proliferation, survival, cell-cycle regulation, and angiogenesis result in tumorigenesis of either TNBC or non-TNBC. Potential interventions for TNBC, at different levels, are included on the right.