Review Article
Phenotypic and Molecular Characterization of MCF10DCIS and SUM Breast Cancer Cell Lines
Table 2
ER, PR, and BRCA1 profile of SUM cell lines.
| | Cell line | BRCA1 |
ER protein |
PR protein |
ERBB2 | | Allelic loss | Mutation | Protein effect |
| | SUM102PT | No loss | Wild type | NA | nd | nd | | | SUM1315MO2 | Loss | 185del AG | truncation | − | − | | | SUM149PT | Loss | 2288delT | truncation | − | − | | | SUM159PT | No loss | Wild type | NA | − | − | | | SUM229PE | No loss | Wild type | NA | − | − | | | SUM185PE | Loss | Wild type | NA | − | − | | | SUM190PT | Loss | Wild type | NA | − | − | +++ | | SUM225CWN | Loss | Wild type | NA | − | − | +++ | | SUM44PE | Loss | Wild type | NA | +++ | +++ | | | SUM52PE | Loss | Wild type | NA | +++ | − | |
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Source: [36, 46, 48]; ER: estrogen receptor, PR: progesterone receptor, NA: not applicable; nd: not determined, −: no expression, +++: overexpression, +: normal expression.
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