Phenotypic and Molecular Characterization of MCF10DCIS and SUM Breast Cancer Cell Lines

Table 7

Summary of mutations affecting the coding sequence of Asterand breast cancer cell lines.

Coding mutations listed in COSMIC database
Cell line	Gene	AA mutation	CDS mutation	Mutation	Zygosity	Reference
MCF10DCIS	PI3KCA	c.3140A>G	p.H1047R	Missense	Unknown	Kalaany and Sabatini (2009) [17]
SUM102PT	CDKN2A	471 del 471	None	Whole gene deletion	Homozygous	Hollestelle et al. (2010) [48]
	PIK3CA	c.3140A>G	p.H1047R	Missense	Heterozygous
SUM1315MO2	BRCA1	66_67 del AG	p.E23fs*17	Frameshift	Homozygous	Hollestelle et al. (2010) [48]
	CDKN2A	471 del 471	None	Whole gene deletion	Homozygous
SUM149PT	FBXW7	c.1644 1645 ins 416	F549Fs*6	Frameshift	Homozygous	Strohmaier et al. (2001) [79]
	BRCA1	c.2169 del T	p.P724fs*12	Frameshift	Homozygous	Hollestelle et al. (2010) [48]
	CDKN2A	471 del 471	None	Whole gene deletion	Homozygous
	EP300	c.4025+(28)del3	unknown	Unknown	Heterozygous	Gayther et al. (2000) [80]
SUM159PT	HRAS	c.35G>A	p.G12D	Missense	Heterozygous	Hollestelle et al. (2007) [69]
	PIK3CA	c.3140A>T	p.H1047L	Missense	Heterozygous
SUM229PE	KRAS	c.35G>A	p.G12D	Missense	Heterozygous	Hollestelle et al. (2010) [48]
	CDKN2A	471 del 471	None	Whole gene deletion	Homozygous
SUM185PE	PIK3CA	3140A>G	p.H1047R	Missense	Heterozygous	Saal et al. (2005) [81]
SUM190PT	PIK3CA	3140A>G	p.H1047R	Missense	Heterozygous	Hollestelle et al. (2007) [69]
SUM225CWN	None
SUM44PE	CDH1	1269delT	F423fs*8	Frameshift	Homozygous	Van de Wetering et al. (2001) [82]
SUM52PE	CDKN2A	203C>T	A68V	Missense	Homozygous	Hollestelle et al. (2010) [48]

Source: [83].