Healthcare Resource Use and Expenditures among Metastatic Breast Cancer Patients Treated with HER2-Targeted Agents
Table 3
Healthcare utilization during follow-up period.
No Treatment
No HER2-targeted agents
HER2-targeted agents
= 2,590
= 12,840
= 2,629
Mean (SD)
Mean (SD)
Mean (SD)
All-cause monthly utilization
Inpatient admissions
0.29 (1.17)
0.15 (0.54)
0.14 (0.65)a
Total inpatient days
1.65 (4.87)
0.87 (3.03)
0.74 (2.32)a
Outpatient utilization
11.49 (14.83)
14.10 (12.93)
16.72 (11.36)a
Emergency department (ED) visits
0.17 (0.61)
0.12 (0.42)
0.13 (0.51)a
Outpatient office visits
1.30 (2.25)
1.70 (1.23)
1.94 (1.17)a
Radiation treatmentc
2.22 (7.60)
2.75 (6.58)
3.05 (5.57)a
Diagnostic radiologyc
1.73 (3.31)
1.78 (2.47)
2.17 (2.39)a
Laboratory services
2.96 (5.69)
4.32 (5.45)
5.27 (5.06)a
Other outpatient cared
3.11 (4.32)
3.42 (3.45)
4.17 (3.11)a
Prescription fills
2.42 (2.65)
3.23 (2.50)
3.16 (2.42)a
Breast cancer monthly utilization
Inpatient admissions
0.07 (0.40)
0.01 (0.17)
0.01 (0.06)a
Total inpatient days
0.47 (3.03)
0.07 (0.63)
0.08 (0.70)a
Outpatient utilization
5.01 (10.04)
8.09 (9.71)
11.00 (8.84)a
Emergency department (ED) visits
0.03 (0.30)
0.02 (0.17)
0.03 (0.18)b
Outpatient office visits
0.65 (2.00)
1.04 (1.01)
1.36 (1.02)a
Radiation treatmentc
1.12 (5.58)
1.63 (5.07)
1.81 (4.21)a
Diagnostic radiologyc
0.68 (2.21)
0.87 (1.55)
1.30 (1.73)a
Laboratory services
1.31 (3.84)
2.79 (4.38)
3.92 (4.13)a
Other outpatient cared
1.20 (2.42)
1.72 (2.03)
2.55 (2.27)a
Office-administered antineoplastic agents
n/a
0.01 (0.07)
0.04 (0.15)a
Outpatient pharmacy antineoplastic agents
n/a
0.28 (0.34)
0.27 (0.35)
value compared with no treatment and no HER2-targeted agents <0.0001. value compared with no treatment and no HER2-targeted agents <0.05.
cRadiation treatment and diagnostic radiology encompass all outpatient radiology services during follow-up.
dOther outpatient care includes all remaining outpatient services that are not reported individually. ePatient monthly utilization is calculated using the following formula: (patient’s total number visits or claims/patient’s total days of follow-up) * 30 days.