Healthcare Resource Use and Expenditures among Metastatic Breast Cancer Patients Treated with HER2-Targeted Agents

Table 3

Healthcare utilization during follow-up period.

	No Treatment	No HER2-targeted agents		HER2-targeted agents
	= 2,590	= 12,840		= 2,629
	Mean (SD)	Mean (SD)		Mean (SD)
All-cause monthly utilization
Inpatient admissions	0.29 (1.17)	0.15 (0.54)		0.14 (0.65)^a
Total inpatient days	1.65 (4.87)	0.87 (3.03)		0.74 (2.32)^a
Outpatient utilization	11.49 (14.83)	14.10 (12.93)		16.72 (11.36)^a
Emergency department (ED) visits	0.17 (0.61)	0.12 (0.42)		0.13 (0.51)^a
Outpatient office visits	1.30 (2.25)	1.70 (1.23)		1.94 (1.17)^a
Radiation treatment^c	2.22 (7.60)	2.75 (6.58)		3.05 (5.57)^a
Diagnostic radiology^c	1.73 (3.31)	1.78 (2.47)		2.17 (2.39)^a
Laboratory services	2.96 (5.69)	4.32 (5.45)		5.27 (5.06)^a
Other outpatient care^d	3.11 (4.32)	3.42 (3.45)		4.17 (3.11)^a
Prescription fills	2.42 (2.65)	3.23 (2.50)		3.16 (2.42)^a
Breast cancer monthly utilization
Inpatient admissions	0.07 (0.40)	0.01 (0.17)		0.01 (0.06)^a
Total inpatient days	0.47 (3.03)	0.07 (0.63)		0.08 (0.70)^a
Outpatient utilization	5.01 (10.04)	8.09 (9.71)		11.00 (8.84)^a
Emergency department (ED) visits	0.03 (0.30)	0.02 (0.17)		0.03 (0.18)^b
Outpatient office visits	0.65 (2.00)	1.04 (1.01)		1.36 (1.02)^a
Radiation treatment^c	1.12 (5.58)	1.63 (5.07)		1.81 (4.21)^a
Diagnostic radiology^c	0.68 (2.21)	0.87 (1.55)		1.30 (1.73)^a
Laboratory services	1.31 (3.84)	2.79 (4.38)		3.92 (4.13)^a
Other outpatient care^d	1.20 (2.42)	1.72 (2.03)		2.55 (2.27)^a
Office-administered antineoplastic agents	n/a	0.01 (0.07)		0.04 (0.15)^a
Outpatient pharmacy antineoplastic agents	n/a	0.28 (0.34)		0.27 (0.35)

value compared with no treatment and no HER2-targeted agents <0.0001.
value compared with no treatment and no HER2-targeted agents <0.05.
^cRadiation treatment and diagnostic radiology encompass all outpatient radiology services during follow-up.
^dOther outpatient care includes all remaining outpatient services that are not reported individually. ^ePatient monthly utilization is calculated using the following formula: (patient’s total number visits or claims/patient’s total days of follow-up) * 30 days.