Research Article
Impact of Undetected Comorbidity on Treatment and Outcomes of Breast Cancer
Table 2
Risk of undetected comorbidity.
| | OR | 95% CI | value | | Lower | Upper |
| Age at cancer diagnosis (years) | | | | | 66–70 | Reference category | 71–75 | 1.12 | 1.02 | 1.22 | 0.02 | 76–80 | 1.28 | 1.17 | 1.39 | <0.0001 | >80 | 1.53 | 1.41 | 1.66 | <0.0001 | Race/ethnicity | | | | | White | Reference category | Black | 1.04 | 0.94 | 1.16 | 0.41 | Hispanic | 0.94 | 0.81 | 1.08 | 0.39 | Other | 0.83 | 0.71 | 0.97 | 0.02 | Year of cancer diagnosis | | | | | 2001 | Reference category | 2002 | 0.99 | 0.91 | 1.07 | 0.75 | 2003 | 0.98 | 0.90 | 1.07 | 0.68 | 2004 | 0.93 | 0.85 | 1.01 | 0.08 | 2005 | 0.92 | 0.84 | 1.00 | 0.05 | Index of prior comorbidity score (NCI Comorbidity Index) | | | | | 0 | Reference category | 1 | 1.20 | 1.13 | 1.28 | <0.0001 | ≥2 | 1.50 | 1.38 | 1.63 | <0.0001 | Indicators of poor performance | | | | | 0 | Reference category | ≥1 | 1.30 | 1.21 | 1.40 | <0.0001 | Stage at diagnosis | | | | | | Reference category | I | 1.66 | 1.49 | 1.85 | <0.0001 | II | 2.40 | 2.15 | 2.67 | <0.0001 | III | 3.26 | 2.87 | 3.71 | <0.0001 | IV | 5.51 | 4.85 | 6.26 | <0.0001 | Histological grade | | | | | Well differentiated | Reference category | Moderately differentiated | 1.11 | 1.02 | 1.20 | 0.01 | Poorly differentiated | 1.15 | 1.05 | 1.26 | <0.01 | Undifferentiated/anaplastic | 1.25 | 1.05 | 1.50 | 0.01 | Missing/unknown | 1.14 | 1.03 | 1.27 | 0.01 | Estrogen (ER) and progesterone (PR) receptor status | | | | | ER and PR negative | Reference category | ER or PR positive | 1.05 | 0.94 | 1.16 | 0.39 | ER and PR positive | 1.00 | 0.92 | 1.09 | 1.00 | Unknown/missing | 1.14 | 1.03 | 1.27 | 0.01 | Percent in census tract with some college | | | | | <25% | Reference category | ≥25% | 0.99 | 0.93 | 1.05 | 0.70 | Percent in census tract living in poverty | | | | | <5% | Reference category | 5–7% | 1.07 | 0.98 | 1.17 | 0.12 | 8–12% | 1.17 | 1.08 | 1.27 | <0.0001 | >12% | 1.34 | 1.25 | 1.45 | <0.0001 | Type of geographic area | | | | | Large metropolitan | Reference category | Metropolitan | 0.97 | 0.91 | 1.04 | 0.42 | Urban | 1.14 | 1.02 | 1.28 | 0.02 | Less urban/rural | 1.09 | 0.99 | 1.20 | 0.08 |
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OR: Odds Ratio; CI: Confidence Interval.
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