Locoregional and Distant Recurrence Patterns in Young versus Elderly Women Treated for Breast Cancer

Table 4

Univariate analysis of risk factors for distant recurrence-free survival in older women.

Characteristic	N^*	Hazard ratio; (95% CI)	HR; value	Log-rank; value
Receptor status
ER/PR+^#	73 (77.66)	0.51 (0.06–4.19)	0.530	0.732
Her2+	8 (8.51)	0.49 (0.01–19.06)	0.706
Triple negative	13 (13.83)	—
Grade
1	26 (26)	0.20 (0.01–6.55)	0.370	0.339
2	42 (42)	1.08 (0.17–6.88)	0.935
3	32 (32)	—
Surgery type
Lumpectomy	92 (87.6)	0.06 (0.01–0.36)	0.002	<0.001
Mastectomy	13 (12.4)	—
Adjuvant chemotherapy
No	95 (90.48)	0.33 (0.04–2.50)	0.282	0.447
Yes	10 (9.52)	—
Neoadjuvant chemotherapy
No	98 (93.33)	0.03 (0.00–0.27)	0.001	<0.001
Yes	7 (6.67)	—
Detected on mammography
No	38 (36.89)	6.44 (0.84–49.11)	0.073	0.022
Yes	65 (63.11)	—
Stage at diagnosis
0/I	68 (65.38)	0.34 (0.06–2.02)	0.237	0.187
II/III	36 (34.62)	—
Nodal status
Positive	24 (22.86)	4.77 (0.81–28.25)	0.085	0.046
Negative	81 (77.14)	—
Postmastectomy radiation
No	3 (23.08)	2.96 (0.27–32.47)	0.374	0.454
Yes	10 (76.92)	—
Postlumpectomy radiation
No	7 (7.61)	3.42 (0.08–141.16)	0.517	0.733
Yes	85 (92.39)	—
Final margin status
Positive	2 (1.96)	4.19 (0.15–115.22)	0.397	0.549
Less than 2 mm	21 (20.59)	0.42 (0.02–11.35)	0.603
Greater than 2 mm	79 (77.45)	—

^*Total patients for each characteristic may vary due to incomplete medical records for some patients.
^#ER/PR+: estrogen receptor/progesterone receptor positive.