Promoter Methylation Status of Breast Cancer Susceptibility Gene 1 and 17 Beta Hydroxysteroid Dehydrogenase Type 1 Gene in Sporadic Breast Cancer Patients
Table 4
Association of BRCA1 promoter methylation with mitosis, immunohistochemistry, and molecular subtype of breast cancer.
Overall ()
%
BRCA1 methylation in normal tissues
BRCA1 methylation in cancer tissues
Methylated (14)
Unmethylated (26)
value
Methylated (17)
Unmethylated (23)
value
Freq.
(%)
Freq.
(%)
Freq.
(%)
Freq.
(%)
Mitosis:
0
4
10.0%
0
(0)
4
(15.4)
0.292
0
(0.0)
4
(17.4)
0.042
1
5
12.5%
3
(21.4)
2
(7.7)
4
(23.5)
1
(4.3)
2
29
72.5%
10
(71.4)
19
(73.1)
13
(76.5)
16
(69.6)
3
2
5.0%
1
(7.1)
1
(3.8)
0
(0.0)
2
(8.7)
Estrogen receptor:
Positive
27
67.5%
10
(71.4)
17
(65.4)
0.912
13
(76.5)
14
(60.9)
0.568
Negative
7
17.5%
2
(14.3)
5
(19.2)
2
(11.8)
5
(21.7)
No available data
6
15.0%
2
(14.3)
4
(15.4)
2
(11.8)
4
(17.4)
Progesterone receptor:
Positive
25
62.5%
9
(64.3)
16
(61.5)
0.985
11
(64.7)
14
(60.9)
0.907
Negative
9
22.5%
3
(21.4)
6
(23.1)
4
(23.5)
5
(21.7)
No available data
6
15.0%
2
(14.3)
4
(15.4)
2
(11.8)
4
(17.4)
Her2:
Positive
10
25.0%
2
(14.3)
8
(30.8)
0.279
2
(11.8)
8
(34.8)
0.007
Negative
19
47.5%
9
(64.3)
10
(38.5)
13
(76.4)
6
(26.1)
No available data
11
27.5%
3
(21.4)
8
(30.8)
2
(11.8)
9
(39.1)
Molecular subtype:
Luminal A
13
32.5%
7
(50.0)
6
(23.1)
0.242
9
(52.9)
4
(17.4)
0.049
Luminal B
9
22.5%
2
(14.3)
7
(26.9)
2
(11.8)
7
(30.4)
Basal-like
2
5.0%
1
(7.1)
1
(3.8)
2
(11.8)
0
(0.0)
Her2
1
2.5%
1
(7.1)
0
(0.0)
0
(0.0)
1
(4.3)
Others
8
20.0%
1
(7.1)
7
(26.9)
2
(11.8)
6
(26.1)
No available data
7
17.5%
2
(14.3)
5
(19.2)
2
(11.8)
5
(21.7)
Chi-square exact test is statistically significant at 95% confidence level.
