Pharmacological Properties to Pharmacological Insight of Sesamin in Breast Cancer Treatment: A Literature-Based Review Study

Table 3

Drug availability evaluation profile sesamin.

Category	Properties	Predictive remarks	Unit
Drug-likeness	Lipinski	Yes	Yes/no
	Veber	Yes	Yes/no
	Muegge	Yes	Yes/no
	Ghose	Yes	Yes/no
	Egan	Yes	Yes/no
	Bioavailability score	0.55	N/A
Absorption	Water solubility	-4.223	Log mol/l
	CaCO2 permeability	1.399	Log Papp (cm/s)
	Intestinal absorption(human)	97.81	% absorbed
	Skin permeability	-2.772	Log Kp
	P-glycoprotein substrate	No	Yes/no
	P-glycoprotein I inhibitor	Yes	Yes/no
	P-glycoprotein II inhibitor	No	Yes/no
Distribution	VDss (human)	-0.17	Log L/kg
	BBB permeability	-0.862	Log BB
	CNS permeability	-2.939	Log PS
Metabolism	CYP450 2C9 substrate	No	Yes/no
	CYP450 2D6 substrate	No	Yes/no
	CYP450 3A4 substrate	No	Yes/no
	CYP450 1A2 inhibitor	Yes	Yes/no
	CYP450 2C9 inhibitor	Yes	Yes/no
	CYP450 2D6 inhibitor	Yes	Yes/no
	CYP450 2C19 inhibitor	Yes	Yes/no
	CYP450 3A4 inhibitor	Yes	Yes/no
Excretion	Total clearance	-0.126	Log ml/min/kg
Toxicity	Skin sensitization	No	Yes/no
	Hepatotoxicity	No	Yes/no
	AMES toxicity	Yes	Yes/no
	hERG I inhibitors	No	Yes/no
	hERG II inhibitors	No	Yes/no
	T. pyriformis toxicity	0.34	Log μg/l
Anticancer effect	P-GP inhibitor	Yes	Yes/no
	Aromatase	No	Yes/no
	ER binding	Yes	Yes/no