Molecular Imaging in Tumor Angiogenesis and Relevant Drug Research
Figure 3
Micro-PET imaging of 18F-FDG, 18F-FLT, and 64Cu-DOTA-RGD4 on hES cell-derived teratoma. (a) Background imaging and bioluminescence imaging show teratoma formation in H9Hes-DF cells in the right shoulder and tumor formation in the control 2008 cell line in the left shoulder ( versus photon/s/cm2/sr, resp.); (b) specific and prominent uptake of 64Cu-DOTA-RGD4 was found in the vascularized teratoma but not in the control human ovarian carcinoma 2008 cell line with low integrin expression (); (c) hES cell-derived teratomas had a low uptake of 18F-FLT, whereas the 2008 cancer xenografts exhibited high 18F-FDG and 18F-FLT uptakes; (d) hES cell-derived teratomas had a low uptake of 18F-FDG, whereas the 2008 cancer xenografts and abdomen exhibited high 18F-FDG and 18F-FLT uptakes (data from Cao et al. [58]).
