Research Article

Optimal Analysis Method for Dynamic Contrast-Enhanced Diffuse Optical Tomography

Figure 4

Comparison among different methods of reconstruction for the absorption coefficient, (māˆ’1), please note that unit of māˆ’1 is used for display purposes. The first and second columns present the reconstructed regular DOT and DCE-DOT absorption maps for B8 using analysis Method no. 2 (reconstructing only). The third and fourth columns show the reconstructed maps using analysis Method no. 3 (taking the source-detector coupling factor into account), while the fifth and sixth columns are for the reconstructed maps using analysis Method no. 4 (MR a priori information is used). When the source-detector coupling factor is considered, the hypersensitivity at the source-detector positions due to coupling errors is reduced. Furthermore, when MRI a priori information is utilized, the inclusion can be clearly identified without background artifacts.
426503.fig.004