Research Article
Feasibility of Imaging Myelin Lesions in Multiple Sclerosis
Table 1
Target/agent properties modeled.
| | Variable | Range of values |
| | Agent molecular weight | 342 Da | | Agent Log | 2–5 | | Agent administered amount | 10−9 moles | | Target | Myelin Basic Protein (MBP) | | Target location | CNS myelin in white matter, gray matter and MS lesions | | Target concentration | | | White matter | 1.015 × 10−3 M | | Gray matter | 1.345 × 10−4 M | | MS lesions | 1.015 × 10−5–3.61 × 10−4 M | | Target molecular weight [25] | 18.5 kDa | | Agent-target binding affinity () | 10−6–10−9 M | | Agent-target association rate () | 105–106 M−1s−1 |
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