Research Article
Feasibility of Imaging Myelin Lesions in Multiple Sclerosis
Table 4
Input parameters used for the sensitivity coefficient calculations.
| | Run no. | Description | Plasma protein binding | Liver microsomal clearance rate |
Log | Target conc. | | k
on | Sensitivity coefficient | | WM/Lesion | GM/Lesion | | | (%) | (mL/min/mg protein) | | (M) | (M) | (M−1s−1) | | |
| | (1) | Baseline | 10 | 8 × 10−3 | 4 | 3.61 × 10−4 | 1 × 10−6 | 5.5 × 105 | — | — | | (2) | % PPB | 20 | 8 × 10−3 | 4 | 3.61 × 10−4 | 1 × 10−6 | 5.5 × 105 | 2.693 × 10−2 | −2.661 × 10−2 | | (3) | LM CL | 10 | 8.8 × 10−3 | 4 | 3.61 × 10−4 | 1 × 10−6 | 5.5 × 105 | 2.534 × 10−2 | −4.785 × 10−2 | | (4) | Log | 10 | 8 × 10−3 | 5 | 3.61 × 10−4 | 1 × 10−6 | 5.5 × 105 | 2.967 × 10−2 | −3.242 × 10−2 | | (5) | Target conc. | 10 | 8 × 10−3 | 4 | 5.42 × 10−4 | 1 × 10−6 | 5.5 × 105 | −3.984 × 10−1 | −3.995 × 10−1 | | (6) | | 10 | 8 × 10−3 | 4 | 3.61 × 10−4 | 2 × 10−6 | 5.5 × 105 | 3.115 × 10−1 | −1.668 × 10−1 | | (7) | | 10 | 8 × 10−3 | 4 | 3.61 × 10−4 | 1 × 10−6 | 1.0 × 106 | −1.526 × 10−5 | −6.893 × 10−5 |
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