Enhanced Extraction of Blood and Tissue Time-Activity Curves in Cardiac Mouse FDG PET Imaging by Means of Constrained Nonnegative Matrix Factorization

Figure 6

Mean value of CNMF and RUDUR weights ( matrix) as determined for CTRL (a) and AMI mouse hearts (b). The difference between the CTRL and AMI weights is displayed in (c) for CNMF and (d) for RUDUR. is the mean value of the ^th basis image over the ^th ROI (). and can be assimilated to the myocardial and LVC RCs, respectively, while and represent the spill-in fraction from the myocardium to LVC and the spill-out fraction from the LVC to the myocardium, respectively. In this figure, we have pooled together the AMI3d and AMI14d groups. denotes .

(a)

(b)

(c)

(d)