Antibiotic-Impregnated Bone Grafts in Orthopaedic and Trauma Surgery: A Systematic Review of the Literature

Table 2

Clinical experience with use of antibiotic-loaded bone grafts in orthopedic and trauma surgery.

Study	Number of patients (n =)	Surgical indication	Infection eradication	Surgery- and infection-related complications	Followup (months)
Allende et al. [8]	12	Posttraumatic infected nonunion of humerus, ulna, and radius	100%	1x transitory radial nerve neurapraxia	19 [12–96]
Borkhuu et al. [9]	154	Spinal fusion for scoliosis	96%	none	31 [11–52]
Buttaro et al. [11]	29	THA	97%	1x periprosthetic fracture; 2x prosthesis dislocations; 4x displacement of greater trochanter	32 [24–60]
Chan et al. [14]	36	Infected tibial nonunions	94%	2x pin tract infection; 2x allergic reactions to antibiotics	44 [36–60]
Chan et al. [15]	46	Infected tibial nonunions	96%	3x pin tract infection; 2x allergic reactions to antibiotics	58 [48–72]
Chen et al. [16]	18	Infected tibial nonunions	100%	5x pin tract infection; 1x knee stiffness	48 [24–74]
English et al. [18]	^*	THA	^*	^*	^*
Khoo et al. [24]	31	THA, TKA, tumor surgery, and hip joint fracture	90%	4x non-union; 3x fracture; 1x ischemia requiring amputation	55 [24–89]
McLaren [7]	17	n.r.	93%	n.r.	n.r.
Michalak et al. [27]	12	THA, TKA		2x hip-, 1x knee dislocation; 1x non-union	47 [14–78]
Seber et al. [33]	7	Postoperative and traumatic chronic OM	100%	none	42 [42–60]
Winkler et al. [35]	48	37x THA; 6x TKA; 3x failed intramedullary nailing; 2x knee empyema	96%	none	38 [12–84]
Winkler et al. [36]	37	THA	92%	none	53 [24–96]

THA: total hip arthroplasty; TKA: total knee arthroplasty; n.r.: not reported; OM: osteomyelitis.
^*Unclear study data; only some of the patients have been treated with AIBGs.