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International Journal of Biomaterials
Volume 2012 (2012), Article ID 582685, 9 pages
http://dx.doi.org/10.1155/2012/582685
Research Article

Polyvinyl Alcohol Hydrogel Irradiated and Acetalized for Osteochondral Defect Repair: Mechanical, Chemical, and Histological Evaluation after Implantation in Rat Knees

1Orthopaedic Biomaterials Laboratory, Faculty of Medical Sciences, University of Campinas (UNICAMP), Rua Tessália Vieira de Camargo, no. 126, Cidade Universitária “Zeferino Vaz”, 13083-887 Campinas, SP, Brazil
2Department of Plastic, Technical College Campinas (COTUCA), University of Campinas (UNICAMP), 13083-887 Campinas, SP, Brazil

Received 10 March 2012; Revised 20 August 2012; Accepted 12 September 2012

Academic Editor: Frank Feyerabend

Copyright © 2012 N. A. Batista et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. H. J. Mankin, H. Dorfman, L. Lippiello, and A. Zarins, “Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data,” Journal of Bone and Joint Surgery A, vol. 53, no. 3, pp. 523–537, 1971. View at Scopus
  2. H. Mankin, V. C. Mow, J. A. Buckwalter, J. P. Iannotti, and A. Ratcliffe, “Articular cartilage structure, composition and function,” in Orthopaedic Basic Science: Biology and Biomechanics of the Musculoskeletal System, J. A. Buckwalter, T. A. Einhorn, and S. R. Simon, Eds., p. 443, American Academy of Orthopaedic Surgeons, 2000.
  3. D. Barnewitz, M. Endres, I. Krüger et al., “Treatment of articular cartilage defects in horses with polymer-based cartilage tissue engineering grafts,” Biomaterials, vol. 27, no. 14, pp. 2882–2889, 2006. View at Publisher · View at Google Scholar · View at Scopus
  4. V. C. Mow, M. H. Holmes, and W. M. Lai, “Fluid transport and mechanical properties of articular cartilage: a review,” Journal of Biomechanics, vol. 17, no. 5, pp. 377–394, 1984. View at Scopus
  5. G. M. Peretti, A. Pozzi, R. Ballis, D. Deponti, and F. Pellacci, “Current surgical options for articular cartilage repair,” Acta Neurochirurgica. Supplement, vol. 108, pp. 213–219, 2011. View at Scopus
  6. W. W. Curl, J. Krome, E. S. Gordon, J. Rushing, B. P. Smith, and G. G. Poehling, “Cartilage injuries: a review of 31,516 knee arthroscopies,” Arthroscopy, vol. 13, no. 4, pp. 456–460, 1997. View at Publisher · View at Google Scholar · View at Scopus
  7. A. E. Beris, M. G. Lykissas, C. D. Papageorgiou, and A. D. Georgoulis, “Advances in articular cartilage repair,” Injury, vol. 36, no. 4, supplement, pp. S14–S23, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. E. B. Hunziker, “Articular cartilage repair: basic science and clinical progress. A review of the current status and prospects,” Osteoarthritis and Cartilage, vol. 10, no. 6, pp. 432–463, 2002. View at Publisher · View at Google Scholar · View at Scopus
  9. L. L. Johnson, “Arthroscopic abrasion arthroplasty historical and pathologic perspective: present status,” Arthroscopy, vol. 2, no. 1, pp. 54–69, 1986. View at Scopus
  10. J. A. Stammen, S. Williams, D. N. Ku, and R. E. Guldberg, “Mechanical properties of a novel PVA hydrogel in shear and unconfined compression,” Biomaterials, vol. 22, no. 8, pp. 799–806, 2001. View at Publisher · View at Google Scholar · View at Scopus
  11. P. C. Kreuz, S. Müller, C. Ossendorf, C. Kaps, and C. Erggelet, “Treatment of focal degenerative cartilage defects with polymer-based autologous chondrocyte grafts: four-year clinical results,” Arthritis Research and Therapy, vol. 11, no. 2, article R33, 2009. View at Publisher · View at Google Scholar · View at Scopus
  12. K. Mithoefer, T. R. McAdams, J. M. Scopp, and B. R. Mandelbaum, “Emerging options for treatment of articular cartilage injury in the athlete,” Clinics in Sports Medicine, vol. 28, no. 1, pp. 25–40, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. R. J. Williams and S. C. Gamradt, “Articular cartilage repair using a resorbable matrix scaffold,” Instructional Course Lectures, vol. 57, pp. 563–571, 2008. View at Scopus
  14. L. Hangody, G. Kish, Z. Kárpáti, I. Szerb, and I. Udvarhelyi, “Arthroscopic autogenous osteochondral mosaicplasty for the treatment of femoral condylar articular defects: a preliminary report,” Knee Surgery, Sports Traumatology, Arthroscopy, vol. 5, no. 4, pp. 262–267, 1997. View at Scopus
  15. L. Hangody and P. Füles, “Autologous osteochondral mosaicplasty for the treatment of full-thickness defects of weight-bearing joints: ten years of experimental and clinical experience,” Journal of Bone and Joint Surgery A, vol. 85, no. 1, pp. 25–32, 2003. View at Scopus
  16. M. Brittberg, A. Lindahl, A. Nilsson, C. Ohlsson, O. Isaksson, and L. Peterson, “Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation,” The New England Journal of Medicine, vol. 331, no. 14, pp. 889–895, 1994. View at Publisher · View at Google Scholar · View at Scopus
  17. I. Martin, D. Schaefer, and B. Dozin, Repair of Osteochondral Lesions, Bookshelf, 2008.
  18. K. Rezwan, Q. Z. Chen, J. J. Blaker, and A. R. Boccaccini, “Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering,” Biomaterials, vol. 27, no. 18, pp. 3413–3431, 2006. View at Publisher · View at Google Scholar · View at Scopus
  19. J. R. Jones, L. M. Ehrenfried, and L. L. Hench, “Optimising bioactive glass scaffolds for bone tissue engineering,” Biomaterials, vol. 27, no. 7, pp. 964–973, 2006. View at Publisher · View at Google Scholar · View at Scopus
  20. C. Liu, C. Gong, Y. Pan et al., “Synthesis and characterization of a thermosensitive hydrogel based on biodegradable amphiphilic PCL-Pluronic (L35)-PCL block copolymers,” Colloids and Surfaces A, vol. 302, no. 1–3, pp. 430–438, 2007. View at Publisher · View at Google Scholar · View at Scopus
  21. S. H. Barbanti, C. A. C. Zavaglia, and E. A. R. Duek, “Polímeros Bioreabsorvíveis na Engenharia de Tecidos,” Polimeros, vol. 15, pp. 13–21, 2005.
  22. V. P. Bavaresco, L. Garrido, N. A. Batista, S. M. Malmonge, and W. D. Belangero, “Mechanical and morphological evaluation of osteochondral implants in dogs,” Artificial Organs, vol. 32, no. 4, pp. 310–316, 2008. View at Publisher · View at Google Scholar · View at Scopus
  23. N. A. Batista, Evaluation Behavior Polyvinyl Alcohol (PVA) Hydrogel Acetalized and Irradiated as Substitute of Articular Cartilage Implanted in Wistar Hannover Rat Knees, Unicamp, 2011.
  24. A. N. Suciu, T. Iwatsubo, M. Matsuda, and T. Nishino, “A study upon durability of the artificial knee joint with PVA hydrogel cartilage,” JSME International Journal C, vol. 47, no. 1, pp. 199–208, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. C. H. Cho, T. Murakami, Y. Sawae et al., “Elasto-plastic contact analysis of an ultra-high molecular weight polyethylene tibial component based on geometrical measurement from a retrieved knee prosthesis,” Proceedings of the Institution of Mechanical Engineers H, vol. 218, no. 4, pp. 251–259, 2004. View at Publisher · View at Google Scholar · View at Scopus
  26. M. Oka, K. Ushio, P. Kumar et al., “Development of artificial articular cartilage,” Proceedings of the Institution of Mechanical Engineers H, vol. 214, no. 1, pp. 59–68, 2000. View at Publisher · View at Google Scholar · View at Scopus
  27. Y. Sawae, T. Murakami, H. Higaki, and S. Moriyama, “Lubrication property of total knee prostheses with PVA hydrogel layer as artificial cartilage,” JSME International Journal C, vol. 39, no. 2, pp. 356–364, 1996. View at Scopus
  28. M. Kobayashi, Y. S. Chang, and M. Oka, “A two year in vivo study of polyvinyl alcohol-hydrogel (PVA-H) artificial meniscus,” Biomaterials, vol. 26, no. 16, pp. 3243–3248, 2005. View at Publisher · View at Google Scholar · View at Scopus
  29. V. P. Bavaresco, Estudo Tribológico de hidrogéis poliméricos para serem utilizados como cartilagem articular artificial [Ph.D. thesis], University of Campinas, Campinas—SP, Brazil, 2004.
  30. Z. Q. Gu, J. M. Xiao, and X. H. Zhang, “Development of a kind of artificial articular cartilage-PVA-hydrogel,” Journal of Biomedical Engineering, vol. 16, no. 1, pp. 13–18, 1999. View at Scopus
  31. A. A. Rodrigues, N. A. Batista, V. P. Bavaresco et al., “Polyvinyl alcohol associated with carbon nanotube scaffolds for osteogenic differentiation of rat bone mesenchymal stem cells,” Carbon, vol. 50, no. 2, pp. 450–459, 2012. View at Publisher · View at Google Scholar · View at Scopus
  32. A. A. Rodrigues, N. A. Batista, V. P. Bavaresco et al., “In vivo evaluation of hydrogels of polyvinyl alcohol with and without carbon nanoparticles for osteochondral repair,” Carbon, vol. 50, no. 6, pp. 2091–2099, 2012. View at Publisher · View at Google Scholar · View at Scopus
  33. S. M. Malmonge, C. A. C. Zavaglia, and W. D. Belangero, “Biomechanical and histological evaluation of hydrogel implants in articular cartilage,” Brazilian Journal of Medical and Biological Research, vol. 33, no. 3, pp. 307–312, 2000. View at Scopus
  34. G. E. Kempson, M. A. R. Freeman, and S. A. V. Swanson, “The determination of a creep modulus for articular cartilage from indentation tests on the human femoral head,” Journal of Biomechanics, vol. 4, no. 4, pp. 239–250, 1971. View at Scopus
  35. R. Jekkings and J. L. de Vries, Practical X-Ray Spectrometry, Springer, New York, NY, USA, 2nd edition, 1970.
  36. J. W. Criss and L. S. Birks, “Calculation methods for fluorescent X-ray spectrometry: empirical coefficients versus fundamental parameters,” Analytical Chemistry, vol. 40, no. 7, pp. 1080–1086, 1968. View at Scopus