Perfusion Flow Enhances Osteogenic Gene Expression and the Infiltration of Osteoblasts and Endothelial Cells into Three-Dimensional Calcium Phosphate Scaffolds

<table>The average length of endothelial cell aggregates was increased in cell-seeded three-dimensional scaffolds and exposed to perfusion flow (<svg height="10.8125" id="M54" style="vertical-align:-0.10033pt" version="1.1" viewbox="0 0 42.912498 10.8125" width="42.912498" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.8125)">
<g transform="translate(72,-63.35)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑛</tspan>
<tspan style="font-size: 12.50px; " x="9.6773224" y="0">=</tspan>
<tspan style="font-size: 12.50px; " x="21.71771" y="0">7</tspan>
<tspan style="font-size: 12.50px; " x="27.969212" y="0">2</tspan>
</text>
</g>
</g>
</svg> aggregates) compared to static conditions (<svg height="10.8125" id="M55" style="vertical-align:-0.10033pt" version="1.1" viewbox="0 0 50.724998 10.8125" width="50.724998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,10.8125)">
<g transform="translate(72,-63.35)">
<text transform="matrix(1,0,0,-1,-71.95,63.5)">
<tspan style="font-size: 12.50px; " x="0" y="0">𝑛</tspan>
<tspan style="font-size: 12.50px; " x="9.6773224" y="0">=</tspan>
<tspan style="font-size: 12.50px; " x="21.71771" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="27.969212" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="34.220711" y="0">4</tspan>
</text>
</g>
</g>
</svg> aggregates).</table>

International Journal of Biomaterials

fig10

Figure 10

Figure 10: Perfusion Flow Enhances Osteogenic Gene Expression and the Infiltration of Osteoblasts and Endothelial Cells into Three-Dimensional Calcium Phosphate Scaffolds 

Figure 10 | Perfusion Flow Enhances Osteogenic Gene Expression and the Infiltration of Osteoblasts and Endothelial Cells into Three-Dimensional Calcium Phosphate Scaffolds 