Table 2: Changes in mRNA levels with perfusion flow (osteoblast cultures) at 1 and 2 days.

Gene7-day fold change 𝑃 value14-day fold change 𝑃 value

VEGF 48%0.020.32
OPN 10%0.030.14
COX-2 67%0.020.25
HIF-l 𝛼 45%0.02