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International Journal of Biomaterials
Volume 2013 (2013), Article ID 240631, 7 pages
http://dx.doi.org/10.1155/2013/240631
Research Article

Blends of Thermoplastic Polyurethane and Polydimethylsiloxane Rubber: Assessment of Biocompatibility and Suture Holding Strength of Membranes

1Department of Chemical Engineering Technology, Yanbu Industrial College, Royal Commission for Jubail and Yanbu, P.O. Box 30436, Yanbu Industrial City 21 477, Saudi Arabia
2Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Poojapura, Thiruvananthapuram, Kerala 695 012, India
3Rubber Technology Centre, Indian Institute of Technology, Kharagpur 721302, India

Received 14 June 2013; Accepted 12 November 2013

Academic Editor: Bikramjit Basu

Copyright © 2013 Krishna Prasad Rajan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

In the present investigation, a compatibilized blend of thermoplastic polyurethane (TPU) and polydimethylsiloxane (PDMS) is prepared by using copolymer of ethylene and methyl acrylate (EMA) as a reactive compatibilizer. Detailed in vitro biocompatibility studies were carried out for this compatibilized blend and the material was found noncytotoxic towards L929 mouse fibroblast subcutaneous connective tissue cell line. Microporosity was created on the surface of membranes prepared from the blend material by adopting the crazing mechanism. Cell proliferation and growth studies on the membranes surface showed that the microporous surface favoured ingrowth of the cells compared with a nonmicroporous surface. Suture holding strength studies indicate that the microporous membranes have enough strength to withstand the cutting and tearing forces through the suture hole. This blend material could be evaluated further to find its suitability in various implant applications.