About this Journal Submit a Manuscript Table of Contents
International Journal of Biomaterials
Volume 2013 (2013), Article ID 412482, 10 pages
http://dx.doi.org/10.1155/2013/412482
Research Article

Bone Response to Surface-Modified Titanium Implants: Studies on the Early Tissue Response to Implants with Different Surface Characteristics

1Institute of Anatomy and Cell Biology, University of Göteborg, Göteborg, Sweden
2Department of Oral and Maxillofacial Surgery, SÄS, 501 82 Borås, Sweden
3Department of Biomaterials, Sahlgrenska Academy at University of Gothenburg, Göteborg, Sweden
4BIOMATCELL VINN Excellence Center of Biomaterials and Cell Therapy, Göteborg, Sweden
5Department of Applied Physics, Chalmers University of Technology, Göteborg, Sweden
6Nano Bridging Molecules SA, 1196 Gland, Switzerland
7Department of Physics and Measurement Technology, Linköping University, Linköping, Sweden
8Department of Chemistry, Materials and Surfaces, SP Technical Research Institute of Sweden, 501 15 Borås, Sweden

Received 9 April 2013; Revised 7 August 2013; Accepted 7 August 2013

Academic Editor: Bikramjit Basu

Copyright © 2013 C. Larsson Wexell et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. C. Larsson, P. Thomsen, J. Lausmaa, M. Rodahl, B. Kasemo, and L. E. Ericson, “Bone response to surface modified titanium implants: studies on electropolished implants with different oxide thicknesses and morphology,” Biomaterials, vol. 15, no. 13, pp. 1062–1074, 1994. View at Publisher · View at Google Scholar · View at Scopus
  2. C. Larsson, L. Emanuelsson, P. Thomsen et al., “Bone response to surface modified titanium implants. Studies on the tissue response after one year to machined and electropolished implants with different oxide thicknesses,” Journal of Materials Science, vol. 8, no. 12, pp. 721–729, 1997. View at Publisher · View at Google Scholar · View at Scopus
  3. C. Larsson, P. Thomsen, B.-O. Aronsson et al., “Bone response to surface-modified titanium implants: studies on the early tissue response to machined and electropolished implants with different oxide thicknesses,” Biomaterials, vol. 17, no. 6, pp. 605–616, 1996. View at Publisher · View at Google Scholar · View at Scopus
  4. B.-O. Aronsson, Preparation and Chacterization of Glow Discharge Modified Titanium Surfaces, Göteborg University, Göteborg, Sweden, 1995.
  5. B.-O. Aronsson, J. Lausmaa, and B. Kasemo, “Glow discharge plasma treatment for surface cleaning and modification of metallic biomaterials,” Journal of Biomedical Materials Research, vol. 35, no. 1, pp. 49–73, 1997.
  6. W. Gombotz and A. Hoffman, “Gas-discharge tecniques for biomaterial modification,” Critical Reviews in Biocompatibility, vol. 4, pp. 1–42, 1987.
  7. B. Kasemo and J. Lausmaa, “Biomaterial and implant surfaces: on the role of cleanliness, contamination, and preparation procedures,” Journal of Biomedical Materials Research, vol. 22, no. 2, pp. 145–158, 1988. View at Scopus
  8. D. C. Smith, R. M. Pilliar, J. B. Metson, and N. S. McIntyre, “Dental implant materials. II. Preparative procedures and surface spectroscopic studies,” Journal of Biomedical Materials Research, vol. 25, no. 9, pp. 1069–1084, 1991. View at Scopus
  9. A. Zhecheva, W. Sha, S. Malinov, and A. Long, “Enhancing the microstructure and properties of titanium alloys through nitriding and other surface engineering methods,” Surface and Coatings Technology, vol. 200, no. 7, pp. 2192–2207, 2005. View at Publisher · View at Google Scholar · View at Scopus
  10. J. W. McGowan and M. J. Malachowski, “Soft x-ray replication of biological material—x-ray microscopy and microchemical analysis of cells,” Annals of the New York Academy of Sciences, vol. 342, pp. 288–303, 1980. View at Scopus
  11. M. Moisana, J. Barbeaub, S. Moreauc, J. Pelletierd, M. Tabrizianc, and L. H. Yahiac, “Low-temperature sterilization using gas plasmas: a review of the experiments and an analysis of the inactivation mechanisms,” International Journal of Pharmaceutics, vol. 226, no. 1-2, pp. 1–21, 2001. View at Publisher · View at Google Scholar
  12. H. Rauscher, O. Kylián, J. Benedikt, A. von Keudell, and F. Rossi, “Elimination of biological contaminations from surfaces by plasma discharges: chemical sputtering,” ChemPhysChem, vol. 11, no. 7, pp. 1382–1389, 2010. View at Publisher · View at Google Scholar · View at Scopus
  13. R. E. Baier and A. E. Meyer, “Implant surface preparation,” The International Journal of Oral & Maxillofacial Implants, vol. 3, no. 1, pp. 9–20, 1988. View at Scopus
  14. R. Baier, A. Meyer, and J. Natiella, “Implant surface physics and chemistry: improvements and impediments to bioadhesion,” in Tissue Integration in Oral, Orthopedic & Maxillofacial Reconstruction, W. Laney and D. Tolman, Eds., pp. 240–249, Quintessence, Chicago, Ill, USA, 1992.
  15. K. Duske, I. Koban, E. Kindel et al., “Atmospheric plasma enhances wettability and cell spreading on dental implant metals,” Journal of Clinical Periodontology, vol. 39, no. 4, pp. 400–407, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. I. Dion, C. Baquey, P. Havlik, and J. R. Monties, “A new model to test platelet adhesion under dynamic conditions. Application to the evaluation of a titanium nitride coating,” International Journal of Artificial Organs, vol. 16, no. 7, pp. 545–550, 1993. View at Scopus
  17. I. Dion, X. Roques, N. More et al., “Ex vivo leucocyte adhesion and protein adsorption on TiN,” Biomaterials, vol. 14, no. 9, pp. 712–719, 1993. View at Publisher · View at Google Scholar · View at Scopus
  18. L. Thair, U. K. Mudali, N. Bhuvaneswaran, K. G. M. Nair, R. Asokamani, and B. Raj, “Nitrogen ion implantation and in vitro corrosion behavior of as-cast Ti-6Al-7Nb alloy,” Corrosion Science, vol. 44, no. 11, pp. 2439–2457, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. I. Braceras, J. I. Alava, J. I. Oate et al., “Improved osseointegration in ion implantation-treated dental implants,” Surface and Coatings Technology, vol. 158-159, pp. 28–32, 2002. View at Publisher · View at Google Scholar · View at Scopus
  20. P. Tengvall, Titanium-Hydrogen Peroxide Interaction With Reference To Biomaterial Applications, University of Linköping, Linköping, Sweden, 1990.
  21. P. Tengvall, H. Elwing, and I. Lundström, “Titanium gel made from metallic titanium and hydrogen peroxide,” Journal of Colloid And Interface Science, vol. 130, no. 2, pp. 405–413, 1989. View at Scopus
  22. P. Tengvall, H. Elwing, L. Sjoqvist, I. Lundstrom, and L. M. Bjursten, “Interaction between hydrogen peroxide and titanium: a possible role in the biocompatibility of titanium,” Biomaterials, vol. 10, no. 2, pp. 118–120, 1989. View at Scopus
  23. P. Tengvall, I. Lundstrom, L. Sjoqvist, H. Elwing, and L. M. Bjursten, “Titanium-hydrogen peroxide interaction: model studies of the influence of the inflammatory response on titanium implants,” Biomaterials, vol. 10, no. 3, pp. 166–175, 1989. View at Scopus
  24. B. Wälivaara, In Vitro Studies of Selected Blood Proteins on Solid Surfaces, Linköping University, Linköping, Sweden, 1996.
  25. G. Davis, M. Natan, and K. A. Anderson, “Study of titanium oxides using Auger line shapes,” Applications of Surface Science, vol. 15, no. 1–4, pp. 321–333, 1983. View at Scopus
  26. J. Griffith, D. Grigg, M. Vasile, P. Russell, and E. Fitzgerald, “Scanning probe metrology,” Journal of Vacuum Science Technology A, vol. 10, no. 4, pp. 674–679, 1992. View at Publisher · View at Google Scholar
  27. A. Wennerberg, On a surface Roughness and Implant Incorporation, Göteborg University, Göteborg, Sweden, 1996.
  28. K. Donath and G. Breuner, “A method for the study of undecalcified bones and teeth with attached soft tissues. The Sage-Schliff (sawing and grinding) technique,” Journal of Oral Pathology, vol. 11, no. 4, pp. 318–326, 1982. View at Scopus
  29. J. Lausmaa, “Surface spectroscopic characterization of titanium implant materials,” Journal of Electron Spectroscopy and Related Phenomena, vol. 81, no. 3, pp. 343–361, 1996. View at Publisher · View at Google Scholar · View at Scopus
  30. I. Bertóti, M. Mohai, J. L. Sullivan, and S. O. Saied, “Surface characterisation of plasma-nitrided titanium: an XPS study,” Applied Surface Science, vol. 84, no. 4, pp. 357–371, 1995. View at Scopus
  31. P. Dawson and K. Tzatzov, “Quantitative auger electron analysis of titanium nitrides,” Surface Science, vol. 149, no. 1, pp. 105–118, 1985. View at Scopus
  32. J. Lausmaa, T. Rostlund, and H. McKellop, “Surface spectroscopic study of nitrogen ion-implanted Ti and Ti-6Al-4V wear against UHMWPE,” Surface and Interface Analysis, vol. 15, no. 5, pp. 328–336, 1990. View at Scopus
  33. E. Roliński, “Mechanism of high-temperature plasma nitriding of titanium,” Materials Science and Engineering C, vol. 100, pp. 193–199, 1988. View at Scopus
  34. H. Tompkins, “Oxidation of titanium nitride in room air and in dry O2,” Journal of Applied Physics, vol. 70, no. 7, pp. 3876–3880, 1991. View at Publisher · View at Google Scholar · View at Scopus
  35. H. Tompkins, “The initial stages of the oxidation of titanium nitride,” Journal of Applied Physics, vol. 71, no. 2, pp. 980–983, 1992. View at Publisher · View at Google Scholar · View at Scopus
  36. M. Vasile, A. Emerson, and F. Baiocchi, “The characterization of titanium nitride by x-ray photoelectron spectroscopy and Rutherford backscattering,” Journal of Vacuum Science Technology A, vol. 8, no. 1, pp. 99–105, 1990. View at Publisher · View at Google Scholar
  37. L. Sennerby, P. Thomsen, and L. E. Ericson, “Early tissue response to titanium implants inserted in rabbit cortical bone. Part I. Light microscopic observations,” Journal of Materials Science, vol. 4, no. 3, pp. 240–250, 1993. View at Scopus
  38. R. Brånemark, A Biomechanical Study of OsseointegRation. In Vivo Measurements in Rat, Rabbit, Dog and Man, Göteborg University, Göteborg, Sweden, 1996.
  39. P. G. Coelho, J. M. Granjeiro, G. E. Romanos et al., “Basic research methods and current trends of dental implant surfaces,” Journal of Biomedical Materials Research B, vol. 88, no. 2, pp. 579–596, 2009. View at Publisher · View at Google Scholar · View at Scopus
  40. K. Healey and P. Ducheyne, “The mechanism of passive dissolution of titanium in a model physological environment,” Journal of Biomedical Materials Research, vol. 26, no. 3, pp. 319–338, 1992. View at Publisher · View at Google Scholar
  41. K. Healy and P. Ducheyne, “Oxidation kinetics of titanium thin films in model physiologic environments,” Journal of Colloid And Interface Science, vol. 150, no. 2, pp. 404–417, 1992. View at Scopus
  42. Y. Tamura, A. Yokoyama, F. Watari, and T. Kawasaki, “Surface properties and biocompatibility of nitrided titanium for abrasion resistant implant materials,” Dental Materials Journal, vol. 21, no. 4, pp. 355–372, 2002. View at Scopus
  43. A. Scarano, M. Piattelli, G. Vrespa, G. Petrone, G. Iezzi, and A. Piattelli, “Bone healing around titanium and titanium nitride-coated dental implants with three surfaces: an experimental study in rats,” Clinical Implant Dentistry and Related Research, vol. 5, no. 2, pp. 103–111, 2003. View at Scopus
  44. S. Durual, P. Rieder, G. Garavaglia, A. Filieri, M. Cattani-Lorente, S. S. Scherrer, et al., “TiNOx coatings on roughened titanium and CoCr alloy accelerate early osseointegration of dental implants in minipigs,” Bone, vol. 52, no. 1, pp. 230–237, 2013. View at Publisher · View at Google Scholar
  45. M. Therin, A. Meunier, and P. Christel, “A histomorphometric comparison of the muscular tissue reaction to stainless steel, pure titanium and titanium alloy implant materials,” Journal of Materials Science, vol. 2, no. 1, pp. 1–8, 1991. View at Publisher · View at Google Scholar · View at Scopus
  46. I. Dion, C. Baquey, B. Candelon, and J. R. Monties, “Hemocompatibility of titanium nitride,” International Journal of Artificial Organs, vol. 15, no. 10, pp. 617–621, 1992. View at Scopus
  47. Y. Yang, S. F. Franzen, and C. L. Olin, “In vivo comparison of hemocompatibility of materials used in mechanical heart valves,” Journal of Heart Valve Disease, vol. 5, no. 5, pp. 532–537, 1996. View at Scopus
  48. V. Karagkiozaki, S. Logothetidis, N. Kalfagiannis, S. Lousinian, and G. Giannoglou, “Atomic force microscopy probing platelet activation behavior on titanium nitride nanocoatings for biomedical applications,” Nanomedicine, vol. 5, no. 1, pp. 64–72, 2009. View at Publisher · View at Google Scholar · View at Scopus
  49. M. Annunziata, A. Oliva, M. A. Basile et al., “The effects of titanium nitride-coating on the topographic and biological features of TPS implant surfaces,” Journal of Dentistry, vol. 39, no. 11, pp. 720–728, 2011. View at Publisher · View at Google Scholar · View at Scopus
  50. R. P. van Hove, P. A. Nolte, C. M. Semeins, and J. Klein-Nulend, “Differences in proliferation, differentiation, and cytokine production by bone cells seeded on titanium-nitride and cobalt-chromium-molybdenum surfaces,” Journal of Biomaterials Applications, vol. 28, no. 2, pp. 278–287, 2013. View at Publisher · View at Google Scholar
  51. P. Rieder, S. Scherrer, A. Filieri, H. W. Wiskott, and S. Durual, “TiNOx coatings increase human primary osteoblasts proliferation independently of the substrate: a short report,” Bio-Medical Materials and Engineering, vol. 22, no. 5, pp. 277–281, 2012.
  52. J. Ellingsen and E. Pinholt, “Pretreatment of titanium implants with lanthanum ions alters the bone reaction,” Journal of Materials Science, vol. 6, no. 3, pp. 125–129, 1995. View at Scopus
  53. M. Abe, “Oxides and hydrous oxides of multivalent metals as inorganic ion exchangers,” in Inorganic Ion Exchange Materials, A. Clearfield, Ed., pp. 179–185, CRC Press, Boca Raton, Fla, USA, 1982.
  54. J. Ellingsen, “Pre-treatment of titanium implants with fluoride improves their retention in bone,” Journal of Materials Science, vol. 6, no. 12, pp. 749–753, 1995. View at Publisher · View at Google Scholar · View at Scopus
  55. C. Johansson, A. Wennerberg, A. Holmén, and J.-E. Ellingsen, “Enhanced fixation of bone to fluoride-modified implants,” in Proceedings of the 6th World Biomatterials Congress, p. 601, Society for Biomaterials, Kamuela, Hawaii, USA, 2000.
  56. D. Kaelble, Physical Chemistry of Adhesion, Wiley Interscience, New York, NY, USA, 1971.
  57. G. Zhao, Z. Schwartz, M. Wieland et al., “High surface energy enhances cell response to titanium substrate microstructure,” Journal of Biomedical Materials Research A, vol. 74, no. 1, pp. 49–58, 2005. View at Publisher · View at Google Scholar · View at Scopus
  58. G. Zhao, A. L. Raines, M. Wieland, Z. Schwartz, and B. D. Boyan, “Requirement for both micron- and submicron scale structure for synergistic responses of osteoblasts to substrate surface energy and topography,” Biomaterials, vol. 28, no. 18, pp. 2821–2829, 2007. View at Publisher · View at Google Scholar · View at Scopus
  59. K. Navaneetha Pandiyaraj, V. Selvarajan, Y. H. Rhee, H. W. Kim, and M. Pavese, “Effect of dc glow discharge plasma treatment on PET/TiO2 thin film surfaces for enhancement of bioactivity,” Colloids and Surfaces B, vol. 79, no. 1, pp. 53–60, 2010. View at Publisher · View at Google Scholar · View at Scopus
  60. D. K. Pattanayak, S. Yamaguchi, T. Matsushita, and T. Kokubo, “Effect of heat treatments on apatite-forming ability of NaOH- and HCl-treated titanium metal,” Journal of Materials Science, vol. 22, no. 2, pp. 273–278, 2011. View at Publisher · View at Google Scholar · View at Scopus
  61. J. H. Park, R. Olivares-Navarrete, R. E. Baier et al., “Effect of cleaning and sterilization on titanium implant surface properties and cellular response,” Acta Biomaterialia, vol. 8, no. 5, pp. 1966–1975, 2012. View at Publisher · View at Google Scholar · View at Scopus
  62. R. A. Gittens, R. Olivares-Navarrete, A. Cheng, et al., “The roles of titanium surface micro/nanotopography and wettability on the differential response of human osteoblast lineage cells,” Acta Biomaterialia, vol. 9, no. 4, pp. 6268–6277, 2013. View at Publisher · View at Google Scholar
  63. Y. Shibata, M. Hosaka, H. Kawai, and T. Miyazaki, “Glow discharge plasma treatment of titanium plates enhances adhesion of osteoblast-like cells to the plates through the integrin-mediated mechanism,” International Journal of Oral and Maxillofacial Implants, vol. 17, no. 6, pp. 771–777, 2002. View at Scopus
  64. T. Youngblood and J. L. Ong, “Effect of plasma-glow discharge as a sterilization of titanium surfaces,” Implant Dentistry, vol. 12, no. 1, pp. 54–60, 2003. View at Scopus
  65. H. Kawai, Y. Shibata, and T. Miyazaki, “Glow discharge plasma pretreatment enhances osteoclast differentiation and survival on titanium plates,” Biomaterials, vol. 25, no. 10, pp. 1805–1811, 2004. View at Publisher · View at Google Scholar · View at Scopus
  66. E. Czarnowska, J. Morgiel, M. Ossowski, R. Major, A. Sowinska, and T. Wierzchon, “Microstructure and biocompatibility of titanium oxides produced on nitrided surface layer under glow discharge conditions,” Journal of Nanoscience and Nanotechnology, vol. 11, no. 10, pp. 8917–8923, 2011. View at Publisher · View at Google Scholar · View at Scopus
  67. G. Giro, N. Tovar, L. Witek, et al., “Osseointegration assessment of chairside argon-based nonthermal plasma-treated Ca-P coated dental implants,” Journal of Biomedical Materials Research A, vol. 101, no. 1, pp. 98–103, 2013.
  68. F. P. Guastaldi, D. Yoo, C. Marin, et al., “Plasma treatment maintains surface energy of the implant surface and enhances osseointegration,” International Journal of Biomaterials, vol. 2013, Article ID 354125, 6 pages, 2013. View at Publisher · View at Google Scholar
  69. B. Walivaara, B.-O. Aronsson, M. Rodahl, J. Lausmaa, and P. Tengvall, “Titanium with different oxides: in vitro studies of protein adsorption and contact activation,” Biomaterials, vol. 15, no. 10, pp. 827–834, 1994. View at Publisher · View at Google Scholar · View at Scopus
  70. H. Aita, N. Hori, M. Takeuchi et al., “The effect of ultraviolet functionalization of titanium on integration with bone,” Biomaterials, vol. 30, no. 6, pp. 1015–1025, 2009. View at Publisher · View at Google Scholar · View at Scopus