Optimisation and In Vivo Evaluation of Pectin Based Drug Delivery System Containing Curcumin for Colon

Table 1

3² factorial batches with their variables.

Trials	Independent variables				Responses
	Coded		Actual		𝑌240	𝑌diff	𝑌Total
	𝑋1	𝑋2	𝑋1	𝑋2
					13.67	80.55	94.23
F1	−1	−1	30	400	11.75	41.17	52.92
F2	0	−1	50	400	9.84	41.07	50.92
F3	1	−1	70	400	17.85	36.84	54.68
F4	−1	0	30	500	18.75	23.84	42.60
F5	0	0	50	500	14.80	22.89	37.69
F6	1	0	70	500	17.40	25.68	43.08
F7	−1	1	30	600	17.05	18.97	36.02
F8	0	1	50	600	16.50	24.59	41.09
F9	1	1	70	600	13.67	80.55	94.23

𝑋1: polymer ratio (pectin); 𝑋2: compression coat weight; 𝑌240: percent drug release after 4 hours; 𝑌_diff: difference in percent drug release between 4th and 6th hour; 𝑌_Total: total percentage of drug release after 6 hours.