Developing a Suitable Model for Water Uptake for Biodegradable Polymers Using Small Training Sets
Table 1
Subset of the library of L-tyrosine-derived polyarylates used in this study.
Polymer
(kDa)
(°C)
Polymer set for model
Predictions
Poly(DTO sebacate)
16
●
Poly(DTB adipate)
42
●
Poly(DTO succinate)
43
●
Poly(DTE adipate)
59
●
Poly(DTE glutarate)
64
●
Poly(DTB succinate)
67
●
Poly(HTH sebacate)
23
●
Poly(HTH adipate)
40
●
Poly(DTM sebacate)
45
●
Poly(DTiP adipate)
55
●
Poly(DTM adipate)
67
●
Poly(HTE succinate)
★
78
●
Poly(DTO adipate)
26
●
Poly(DTsBR(+)methyladipate)
45
●
Poly(DTsB R(+) glutarate)
46
●
Poly(DTM R(+) methyladipate)
53
●
Poly(DTBn adipate)
61
●
Poly(HTE adipate)
61
●
Poly(DTO suberate)
21
●
Poly(DTH suberate)
24
●
Poly(HTH suberate)
27
●
Poly(DTO glutarate)
32
●
Poly(DTiB sebacate)
33
●
Poly(DTH R(+) methyladipate)
33
●
Poly(DTH L(−) methyladipate)
33
●
Poly(DTH adipate)
34
●
Poly(DTB R(+) methyladipate)
35
●
Poly(DTB L(−) methyladipate)
35
●
Poly(DTB suberate)
37
●
Poly(DTO diglycolate)
40
●
Poly(DTBn sebacate)
42
●
Poly(DTH glutarate)
43
●
Poly(DTH diglycolate)
45
●
Poly(DTsB L(−) methyladipate)
45
●
Poly(DTsB L(−) glutarate)
46
●
Poly(DTsB R(+) suberate)
46
●
Poly(DTsB L(−) suberate)
46
●
Poly(DTsB R(+) adipate)
50
●
Poly(DTsB L(−) adipate)
50
●
Poly(DTB glutarate)
50
●
Poly(DTH succinate)
53
●
Poly(DTM L(−) methyladipate)
53
●
Poly(HTE suberate)
54
●
Poly(DTiP R(+) methyladipate)
54
●
Poly(DTiP L(−) methyladipate)
54
●
Poly(DTM suberate)
55
●
Poly(DTBn R(+) methyladipate)
55
●
Poly(DTBn L(−) methyladipate)
55
●
Poly(DTiB adipate)
56
●
Poly(DTE R(+) methyladipate)
63
●
Poly(DTE L(−) methyladipate)
63
●
Poly(HTE R(+) methyladipate)
63
●
Poly(HTE L(−) methyladipate)
63
●
Poly(DTB diglycolate)
64
●
Poly(DTiB succinate)
75
●
The “” symbol indicates the presence of more than one chiral center in the polymer repeat unit. Molecular weight ( was measured by THF-GPC (mean value of three different films ± standard deviation (SD)). The “” symbol indicates the polymers that did not dissolve in THF and, thus, could not be measured, and degradation could not be measured. Glass transition temperature ( was measured by DSC for the dry polymer before pressing.
