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Authors | Year | Technique | Advantage(s) | Disadvantage(s) | Application |
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Chen and Su [36] | 2011 | Electrospinning with plasma treatment | Enhanced chondrocytes viability and proliferation | N/A | Cartilage tissue engineering |
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Coburn et al. [37] | 2012 | Biological cue chondroitin sulfate incorporated electrospinning | Enhanced cartilaginous formation | Weak mechanical properties | Cartilage tissue engineering |
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Shabani et al. [38] | 2012 | Modified setup of electrospinning with heat from halogen light bulbs | Improved cell infiltration rate | Material limitation | Tissue engineering |
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Kai et al. [39] | 2012 | Nanofiber with hydrogel | Relatively higher compressive strength | No significant cell proliferation improvement | Tissue regeneration |
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Xu et al. [13] | 2012 | Hybrid inkjet printing/electrospinning system | High cell viability, formed cartilage-like structure | Further refinement required | Cartilage tissue engineering |
|
Wei et al. [40] | 2012 | Electrospinning | Improved cell attachment and proliferation | N/A | Cartilage tissue engineering |
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Holmes et al. [41] | 2013 | Hydrogen treated multiwalled carbon nanotubes (MWCNTs) | Higher mechanical strength and cell differentiation | Unclear effect of MWCNTs in vivo | MSC chondrogenesis
|
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Cai et al. [42] | 2013 | Electrostatic repulsion | Randomly and evenly oriented 3D fibers | Rapid delivery of electrons on fibers required | Cell culture for soft tissues |
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Yunos et al. [43] | 2013 | Bilayered scaffold | Chondrocyte cell-supporting ability | Decreased HA formation rate with thicker layer | Osteochondral tissue replacement |
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Levorson et al. [44] | 2013 | Dual extrusion electrospinning | Maintained scaffold cellularity | Lack of parameter optimization | Cartilage tissue engineering |
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Xue et al. [45] | 2014 | Prepare the electrospun membrane in rounded shape | Formed ear-shaped cartilage tissue | Lack of immunogenicity investigation | Cartilage tissue engineering |
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Garrigues et al. [46] | 2014 | Electrospinning | Enhanced cell infiltration | Lower elastic modulus | Cartilage tissue engineering |
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Xu et al. [47] | 2014 | Electrospinning solution with de-cross-linked keratin from chicken feathers | Intrinsic water stability | Randomly oriented fibers | Cell penetration and differentiation |
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Orr et al. [48] | 2015 | Vertical stacking layers of fiber membrane | Easy to seed cells on surface prior to stacking | Cells unable to penetrate through layers | Compressive loading applications |
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Liu et al. [49] | 2015 | Electrospinning and freeze drying | Better mechanical strength | N/A | Cartilage tissue engineering |
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Zhu et al. [50] | 2015 | Electrospinning with cold atmospheric plasma treatment | Enhanced chondrogenic differentiation and cell infiltration | Small thickness for 3D scaffold | Cartilage tissue engineering |
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Chen et al. [51] | 2016 | Modified scaffold with cross-linked hyaluronic acid | Superabsorbent property and excellent cytocompatibility | Complicated fabrication process | Cartilage tissue engineering |
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Afonso et al. [52] | 2016 | Direct writing electrospinning | Directed tissue organization and fibril matrix orientation | Microscale fibers | Tissue engineering |
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Damaraju et al. [53] | 2017 | Piezoelectric fibrous scaffolds | Promoted mesenchymal stem cell differentiation | N/A | Cartilage and bone tissue engineering |
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