Fabrication and Characterization of Chitosan-Polyethylene Glycol (Ch-Peg) Based Hydrogels and Evaluation of Their Potency in Rat Skin Wound Model

Figure 7

(a) Improvement of wound healing using hydrogel composites in an experimental second-degree burn of rat skin. Wounds treated with X : Ge : Peg : Ch : G, X : Ge : B : Peg : G, and X : Ge : B : Peg : Ch:G recovered the most after 28 days when compared to other hydrogel compositions. The presence of Peg and Ch in the formulations may explain for the hydrogel composites considerable wound contraction. Abbreviations. Xanthan gum (X), boric acid (B), gelatin (Ge), polyethylene glycol (Peg), chitosan (Ch), and glutaraldehyde (G). (b) Diagram of wound healing contraction rate. At the end of 28 days treatment period wound area of 28th day was analyzed using a two-way ANOVA coupled with Bonferroni posthoc test. Significantly different from control, none of the hydrogel treated groups were significantly different from the povisep group (). Abbreviations. Xanthan gum (X), boric acid (B), gelatin (Ge), polyethylene glycol (Peg), chitosan (Ch), and glutaraldehyde (G).

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