The Response of Creatine Kinase Specific Activity in Rat Pituitary to Estrogenic Compounds and Vitamin D Less-Calcemic Analogs

Figure 10

The effect of pretreatment with JKF and QW at 0.2 ng/g/rat/day for 3 days in immature female rats (a) or 1 week in Ovx female rats (lower panel) on CK activity compared to the stimulation by E₂ at 5𝜇g/rat or Ral at 500 𝜇g/rat or both, and to the combination of the vitamin D analogs with E₂, Ral, or both. Treatments were as described in Section 2. Results are expressed as the ratios between the specific activities of CK in hormone-treated and vehicle-injected control animals. The basal activity of CK in was 0.78+0.10𝜇mol/min/mg protein for Ovx and 1.02+0.12𝜇mol/min/mg protein for immature female rats, 𝑛=5. ^∗𝑃<.05, ^∗∗𝑃<.01, in the difference compared to vehicle.

(a)

(b)