The Response of Creatine Kinase Specific Activity in Rat Pituitary to Estrogenic Compounds and Vitamin D Less-Calcemic Analogs

Figure 9

The effect of pretreatment with JKF and QW at 0.2 ng/g/rat/d for 10 weeks (a), 1 week (b) or 3 days (c) on CK activity in Pi from OVX female rats compared to the stimulation of E₂ at 5𝜇g/rat and to the combination of the vitamin D analogs and E₂. Treatments were as described in Section 2. Results are expressed as the ratios between the specific activities of CK in hormone-treated and vehicle-injected control animals. The basal activity of CK in was 0.76+0.08𝜇mol/min/mg protein, 𝑛=5. ^∗𝑃<.05, ^∗∗𝑃<.01 in the difference compared to vehicle.

(a)

(b)

(c)