The Small Heat Shock Protein HSP25/27 (HspB1) Is Abundant in Cultured Astrocytes and Associated with Astrocytic Pathology in Progressive Supranuclear Palsy and Corticobasal Degeneration

Figure 3

Expression of PHF-1 tau and HSP27 in globus pallidus of patients with PSP and CBD in comparison to unaffected control (Co). Adjacent sections were immunostained with PHF-1 (left) or HSP27 (right). PHF-1 staining demonstrates robust tau pathology in the affected brain regions. No pathology was detected in the brains of unaffected controls, while PSP and CBD brains show characteristic glial pathology and PHF-1 positive threads.