Conserved Molecular Mechanisms Underlying Homeostasis of the Golgi Complex

Table 2

Evolutionarily conserved molecules, machineries, and principles involved in intra-Golgi transport that could underlie the homeostasis of the Golgi complex.

Mammals	Yeast	Comment
Lipid metabolism Cholesterol/sphingolipids	Lipid metabolism Ergosterol/sphingolipids	Protein organization due to affinity for lipid subdomains
PI4KIII𝛽	Pik1	Same regulatory mechanism underlying PI(4)P metabolism
Sac1	Sac1
GOLPH3	VPS74	Coincidence detector for Golgi resident localisation
PI(4)P	PI(4)P
(COPI)	COPI
COPI	COPI	Different isoforms distributed over the Golgi
ArfGAPs	ArfGAPs	Different isoforms distributed over the Golgi
ArfGEFs	ArfGEFs
Arf1	Arf1	Distributed over the Golgi
GOG1-4, GOG5-8	GOG1-4, GOG5-8	Two conserved COG subcomplexes
Rab6	Ypt6	Small GTPase governing retrograde transport
SNAREs	SNAREs	Same basic distribution in the Golgi