Designing a Long Acting Erythropoietin by Fusing Three Carboxyl-Terminal Peptides of Human Chorionic Gonadotropin Subunit to the N-Terminal and C-Terminal Coding Sequence
Figure 7
In vivo half-life of EPO variants. Mice were injected IV with 20 IU of rHuEPO, Aranesp and EPO-(CTP)3 and blood samples were drawn at the indicated times. Serum levels of EPO were determined by RIA. Mean ± SE of 5 determinations. Basal EPO levels before treatment were unmeasured.
