Doxorubicin Induced Nephrotoxicity: Protective Effect of Nicotinamide

Table 1

The activities of catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH), and protein oxidation (Po) levels in renal tissue of control (𝑛=6), NAD (𝑛=8), DXR (𝑛=8), and DXR plus NAD groups (𝑛=8). *𝑃=0.001; control versus NAD, DXR, and N + D, **𝑃=0.105; control versus N + D.

	Markers
Groups	GSH (μmoL/mg protein)	GPx (μmoL/μg)	CAT (μmoL/μg)	Protein oxidation (nmoL/μg)
Control	5.32 ± 1.39	1.73 ± 0.38	9.16 ± 4.16	0.35 ± 0.04
NAD	4.85 ± 1.15*	0.60 ± 0.11*	4.61 ± 0.36*	0.15 ± 0.02*
DXR	2.22 ± 1.06*	0.41 ± 0.17*	3.84 ± 0.99*	4.32 ± 0.20*
DXR + NAD	4.90 ± 0.9**	1.48 ± 0.15*	20.01 ± 7.40*	0.68 ± 0.11*