Plastin Family of Actin-Bundling Proteins: Its Functions in Leukocytes, Neurons, Intestines, and Cancer

Table 2

Studies on L-plastin in leukocytes.

Leukocyte types	Key words of the study	References
Innate immunity
Macrophages	Bacterial lipopolysaccharide (LPS)-induced activation	[8–10, 12]*, [13, 14]
Macrophages	Grancalcin and host defence	[15]
Macrophages	IL-1/TNF-induced activation	[16]*
Macrophages	Podosome formation	[17]
Macrophages	Zebrafish and lineage marker	[18–20]
Macrophages	Toxoplasma gondii-infection	[21]
Neutrophils	IL-8-induced activation	[22]*
Neutrophils	Fc receptor and phagocytosis	[23, 24]*
Neutrophils	L-plastin KO^# and integrin	[25, 26]*
Eosinophils	GM-CSF-induced priming	[27]*
Osteoclasts	Podosome formation	[28]
Osteoclasts	Sealing ring formation	[29]
Adaptive immunity
T-cells	IL-2-induced activation	[30]*
T-cells	Accessory receptors	[31]*
T-cells	Lymphokine-activated killer cells	[32]*
T-cells	Costimulation	[33]*
T-cells	CCR7 and thymus	[34]
T-cells	LFA-1 and immune synapse	[35]
T-cells	L-plastin KO^# and impaired T cell responses	[36]
B-cells	Marginal zone B cell development	[37]
Suppression immunotherapies targeting L-plastin
Leukocytes	Cannabinoid receptor agonists	[38]
Leukocytes	Glucocorticoid dexamethasone	[39]

*These studies addressed the L-plastin phosphorylation in leukocytes.
^#Disruption of the L-plastin gene in mice.